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https://hdl.handle.net/10119/9191
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| Title: | Evaluation of genotoxicity of amine-terminated water-dispersible FePt nanoparticles in the Ames test and in vitro chromosomal aberration test |
| Authors: | Maenosono, Shinya
Yoshida, Rie
Saita, Soichiro |
| Keywords: | FePt nanoparticle
2-aminoethanethiol
Cysteamine
Genotoxicity
Bacterial reverse mutation assay
Chromosomal aberration test |
| Issue Date: | 2009 |
| Publisher: | 日本トキシコロジー学会 |
| Magazine name: | The Journal of Toxicological Sciences |
| Volume: | 34 |
| Number: | 3 |
| Start page: | 349 |
| End page: | 354 |
| DOI: | 10.2131/jts.34.349 |
| Abstract: | Genotoxicity of superparamagnetic iron-platinum (FePt) nanoparticles (NPs) capped with 2-aminoethanethiol (AET) was evaluated using the bacterial reverse mutation assay (Ames test) and in vitro chromosomal aberration test. Mutagenicity of AET-capped FePt NPs was found to be negative in the Ames test, while clastogenicity of FePt NPs seemed to be false-positive in the in vitro chromosomal aberration test using Chinese hamster lung fibroblast cells. However, further detailed in vitro genotoxicity tests, such as DNA adduct studies, are necessary to conclude that a positive aberration result is irrelevant. |
| Rights: | Copyright (C) 2009 日本トキシコロジー学会. Shinya Maenosono, Rie Yoshida, and Soichiro Saita, The Journal of Toxicological Sciences, 34(3), 2009, 349-354. http://dx.doi.org/10.2131/jts.34.349 |
| URI: | https://hdl.handle.net/10119/9191 |
| Material Type: | publisher |
| Appears in Collections: | c10-1. 雑誌掲載論文 (Journal Articles)
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