|
JAIST Repository >
c. マテリアルサイエンス研究科・マテリアルサイエンス系 >
c11. 会議発表論文 >
c11-1. 会議発表論文 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10119/9554
|
| タイトル: | Model-Membrane Morphological Transformations Induced by Different Amyloid Molecular Assemblies |
| 著者: | Morita, Masamune
Vestergaard, Mun'delanji
Hamada, Tsutomu
Takagi, Masahiro |
| キーワード: | Amyloid beta
Alzheimer's disease
membrane
transformation |
| 発行日: | 2009 |
| 出版者: | Institute of Electrical and Electronics Engineers (IEEE) |
| 誌名: | International Symposium on Micro-NanoMechatronics and Human Science, 2009. MHS 2009 |
| 開始ページ: | 220 |
| 終了ページ: | 224 |
| DOI: | 10.1109/MHS.2009.5352033 |
| 抄録: | Amyloid beta (Ab) has been strongly implicated in inducing neurotoxicity in the pathology of Alzheimer's disease (AD). However、 the underlying mechanisms remain unknown. In this study、 we examined、 in real-time、 the spatio-temporal changes in individual model membranes induced by the presence of different Ab-40 molecular assemblies (species). We used cell-sized lipid vesicles to enable the direct observation of these changes. We found two significantly different membrane-transformation pathways. We characterized the biophysical mechanisms behind these transformations in terms of the change in inner vesicle volume and surface area. Interestingly、 mature fibrils、 which are often considered inert species、 also induced profound membrane changes. The real-time observation of these morphological transformations、 which can be missed in a discretised analysis、 may help to unlock the mechanisms of Alzheimer's Ab-induced neuro-degeneration. |
| Rights: | Copyright (C) 2009 IEEE. Reprinted from International Symposium on Micro-NanoMechatronics and Human Science, 2009. MHS 2009, 220-224. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of JAIST's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. By choosing to view this document, you agree to all provisions of the copyright laws protecting it. |
| URI: | http://hdl.handle.net/10119/9554 |
| 資料タイプ: | publisher |
| 出現コレクション: | c11-1. 会議発表論文 (Conference Papers)
|
このアイテムのファイル:
| ファイル |
記述 |
サイズ | 形式 |
|---|
| 15775-1.pdf | | 724Kb | Adobe PDF | 見る/開く |
|
当システムに保管されているアイテムはすべて著作権により保護されています。
|
